The Children’s Cancer Centre (CCC) at The Royal Children’s Hospital (RCH) opened in October 2006. The CCC is the only provider of complex children's cancer care and stem cell transplantation in the state of Victoria. The CCC is recognised as an international leader in the research and treatment of childhood cancer, each year treating around 300 newly diagnosed cancer patients under the age of 18 and many children receive ongoing treatment and/or active patient follow up. 

The CCC aims for the highest standards in diagnosis, research, treatment, and support. The CCC comprises inpatient wards with designated bone marrow transplant beds, a day oncology unit, and outpatient clinic area including allied health facilities, a dedicated oncology pharmacy, and a research program with state-of-the-art laboratory facilities, a clinical trials office and an administrative centre.